Nucleophosmin breast cancer

It will be important to further understand which post-translational modifications may occur at these key areas and how these would affect the various roles attributed to NPM1, including its nucleolar chaperone and cell cycle functions. Finally, mutations that affect nucleophosmin oligomer formation also changed recognition and cleavage by granzyme B. Rapid Commun Mass Spectrom NPM1 upregulates CDH1 levels, which accelerate Skp2 degradation, thereby mediating the ubiquitination of p27 kip1 , and then induce the proliferation in breast cancer. Deng Y, Smith DL Rate and equilibrium constants for protein unfolding and refolding determined by hydrogen exchange-mass spectrometry.
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Phase Separation in the Nucleolus

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Clarke Labs

Therefore depriving nucleoli of NPM1 might cause nucleolar stress and induce an apoptotic response. We apply a translational approach, where observations in experimental systems are further explored in human breast cancer specimens and vice versa. Nucleophosmin B23 targets ARF to nucleoli and inhibits its function. Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation. Open in a separate window.
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Contribution of nucleophosmin overexpression to multidrug resistance in breast carcinoma.

Bovine serum albumin, carrier protein, conjugation. Supplied as a liquid in ascitic fluid containing 0. Write a review for PA Moreover, YTR significantly potentiated radiation-induced growth delay in HT29 tumour xenografts [ ]. Neoplasms, Experimental Antibodies. These modifications prevent SDS molecules from binding to the target protein and thus make the band size appear larger than expected 2.
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The specific contribution of overexpressed NPM1 to cancer development is not fully understood but it may arise from multiple factors. This article has been cited by other articles in PMC. Nat Rev Mol Cell Biol. Frontiers As summarized here, NPM1 plays multiple roles within human cells while the best documented is in RNA transport and ribosome biogenesis, it is clear that NPM1 also plays a critical role in the regulation of apoptosis and in the maintenance of genomic homeostasis. Cochrane Database Syst Rev. Dr Ahmet Emre Eskazan.
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